General features

Gene IDMYPE6880
TypeCDS
From884863
To884015
Strand-
General namefolD
Definitionmethylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase
nt length849
aa length282
m.w.31096.04
COG[H] Coenzyme metabolism

Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
mpneMPN017 mtd1 5,10-methylene-tetrahydrofolate dehydrogenase 18989:181801064.3e-29
mgenWP_009885972.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma genitalium]1143.3e-32
mpulWP_041364009.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma pulmonis]1089.0e-30
mmobWP_011264680.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma mobile]1378.6e-41
mmycNP_975734.1 bifunctional protein FolD [Mycoplasma mycoides subsp. mycoides SC str. PG1]1477.1e-45
mgalWP_011113977.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Mycoplasma gallisepticum]877.2e-22
uureWP_004025975.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Ureaplasma urealyticum]744.2e-17
bsubNP_390311.1 methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. subtilis str. 168]1902.0e-60
caceWP_010965383.1 MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Clostridium]1943.6e-62
ecoliNP_415062.1 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Escherichia coli str. K-12 substr. MG1655]1667.9e-51

*mpne, Mycoplasma pneumoniae; mgen, Mycoplasma genitalium; mpul, Mycoplasma pulmonis; mmob, Mycoplasma mobile; mmyc, Mycoplasma mycoides; mgal, Mycoplasma gallisepticum; uure, Ureaplasma urealyticum; bsub, Bacillus subtilis; cace, Clostridium acetobutylicum; ecoli, Escherichia coli K-12;

Pfam search result:



ModelNo.Descrip tionPosition (aa)ScoreE-value

THF_DHG_CYH_C1Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain134-276185.44.4e-55

THF_DHG_CYH1Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain2-11698.92.2e-28

BLAST search result (top 10 hits)

ID DescriptionIdentityScoreE-value
ref|WP_011077510.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pene...282/282 (100%)14490.0e+00
ref|WP_004024965.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma iowa...132/280 (47%)6262.3e-77
ref|WP_119567768.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Inordinaticella...118/270 (43%)5837.7e-71
ref|WP_132766902.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Tepidibacillus ...120/278 (43%)5793.3e-70
ref|WP_139489318.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Brevibacillus s...122/277 (44%)5794.0e-70
ref|WP_121520991.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Oceanobacillus ...121/274 (44%)5778.2e-70
ref|WP_069657703.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Vulcanibacillus...114/274 (41%)5778.5e-70
ref|WP_039764483.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Caldicellulosir...127/270 (47%)5751.6e-69
ref|WP_055275492.1| MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/met... [Turicibacter]121/269 (44%)5708.3e-69
ref|WP_084157673.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydr... [Exiguobacterium...113/275 (41%)5691.1e-68

Maintained by Jun Ishikawa