General features

Gene IDMPN017
TypeCDS
From18989
To18180
Strand-
General namemtd1
Definition5,10-methylene-tetrahydrofolate dehydrogenase
nt length810
aa length269
m.w.30203.91
COG[H] Coenzyme metabolism

Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
mypeMYPE6880 folD methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase 884863:8840151133.1e-31
mgenWP_009885972.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma genitalium]3661.3e-130
mpulWP_041364009.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma pulmonis]1122.4e-31
mmobWP_011264680.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Mycoplasma mobile]1167.4e-33
mmycNP_975734.1 bifunctional protein FolD [Mycoplasma mycoides subsp. mycoides SC str. PG1]1288.4e-38
mgalWP_011113977.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Mycoplasma gallisepticum]1342.6e-39
uureWP_004025975.1 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Ureaplasma urealyticum]676.4e-15
bsubNP_390311.1 methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. subtilis str. 168]1432.8e-42
caceWP_010965383.1 MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Clostridium]1021.3e-26
ecoliNP_415062.1 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Escherichia coli str. K-12 substr. MG1655]1194.5e-33

*mype, Mycoplasma penetrans; mgen, Mycoplasma genitalium; mpul, Mycoplasma pulmonis; mmob, Mycoplasma mobile; mmyc, Mycoplasma mycoides; mgal, Mycoplasma gallisepticum; uure, Ureaplasma urealyticum; bsub, Bacillus subtilis; cace, Clostridium acetobutylicum; ecoli, Escherichia coli K-12;

Pfam search result:



ModelNo.Descrip tionPosition (aa)ScoreE-value

THF_DHG_CYH_C1Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain121-264116.37.6e-34

THF_DHG_CYH1Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain4-11196.31.3e-27

BLAST search result (top 10 hits)

ID DescriptionIdentityScoreE-value
ref|WP_010874374.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pneu...269/269 (100%)14320.0e+00
ref|WP_054175383.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pneu...268/269 (99%)14290.0e+00
ref|WP_014325285.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pneu...268/269 (99%)14280.0e+00
ref|WP_053343992.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pneu...267/269 (99%)14260.0e+00
ref|WP_054175819.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma pneu...267/269 (99%)14230.0e+00
ref|WP_009885972.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma geni...174/267 (65%)9394.3e-125
ref|WP_014893893.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma geni...173/267 (64%)9342.0e-124
ref|WP_014894095.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma geni...173/267 (64%)9342.4e-124
ref|WP_027119786.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma test...108/266 (40%)4983.4e-58
ref|WP_027123752.1| bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-metheny... [Mycoplasma piru...99/268 (36%)4426.9e-50

Maintained by Jun Ishikawa